I'm pretty sure it will bolt right up, typical SBC bellhousing. I don't know much about the 2wd NV4500's however the 4x4 models suffer from oiling issues which result in early failure of 4th and 5th gear. May want to research the details before spending your cash and having something go wrong.
I'm also looking into replacing my 700r4 with a 5 speed... not sure what I'm going to use yet but was thinking about a tremec/kreissler, pretty pricey though.
Keep us posted.